The Paolo Orsi Archaeological Museum in Syracuse is one of the largest archaeological museums in Europe. It is located on the Terraferme, 800 meters northwest of the complex of the Church of St. Lucia at the tomb.

The history of the museum dates back to 1780, when the Seminary Museum was founded by the city archbishop. In 1808, this museum was transformed into a city museum, and in 1878, by royal decree, it received the status of the National Museum of Syracuse. Since 1886, the museum's collections have been housed in buildings on Cathedral Square.

From 1895 to 1934, the museum was headed by Paolo Orsi, the most prominent Italian archaeologist, researcher of the ancient and prehistoric heritage of Italy. After the death of the scientist, the museum's funds continued to be replenished with new finds, and over time, a need arose for a new building. It was built in 1988 near Landolina's villa. The new building contained an exhibition area of ​​9,000 square meters and a spacious conference hall.
The basis of the museum's funds are artifacts found in the cities and other areas of Sicily and covering the period from prehistoric times to the time of the Roman Empire. The first floor is divided into three exhibition sectors (A, B, C), and in the central building there is space for a small exhibition dedicated to the history of the museum (Area 1).
Sector A contains archaeological finds from the Paleolithic to the Iron Age. Here you can see fossils and other fossils that testify to prehistoric life forms. In addition, artifacts related to the geology of the ancient Mediterranean are shown here. Sector B is dedicated to the Sicilian Greek colonies of the Ionic and Doric periods. Here you can see a map showing the most important archaeological areas, as well as works of ancient art: the figure of a young man from the 5th century BC, the remains of Doric columns, figurines of Greek gods and other finds. Sector C shows finds relating to the period of the Greek sub-colonies (7-6 centuries BC). In 2006, new exhibition halls on the second floor were equipped, where finds from the classical and Roman periods are now presented. Among the most interesting exhibits are Venus Landolinsky and the sarcophagus of Adelphia.

Next to the museum is a small park where you can see additional ancient Roman and Greek artifacts, as well as the tomb of the German poet August von Platen.