The building was built at the beginning of the sixteenth century, a period when the Marescotti and Bentivoglio families were fighting each other. Ercole Marescotti de Calvi, in alliance with Pope Julius II, was one of the supporters of the destruction of the Bentivoglio Palace in 1507. It is believed that the current portal already belonged to the grandiose residence of the rulers of Bologna. In revenge, some people led by Gaspare Scappi and Galeazzo Poeti destroyed Marescotti's house. The papal legate Francesco Alidozio commissioned Giovanni Beroaldo to reconstruct the building, but the facade above the portico is still unfinished.→